RT Journal Article
SR Electronic
T1 Treating vasculitis with conventional immunosuppressive agents
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S46
OP S49
DO 10.3949/ccjm.79.s3.10
VO 79
IS 11 suppl 3
A1 Jayne, David
YR 2012
UL http://www.ccjm.org/content/79/11_suppl_3/S46.abstract
AB Standard therapy for granulomatosis with polyangiitis and other vasculitides is a combination of cyclophosphamide and glucocorticoids. Although most patients achieve remission, relapses and treatment-related morbidities are common. Clinical trials have yielded a wealth of data about less toxic alternatives to standard therapy, including new agents and methods of delivery. All aim to reduce long-term exposure to cyclophosphamide and glucocorticoids and so maintain safety while effectively preventing relapse. Individualized evaluation of risk and treatment selection will help maximize effectiveness and minimize toxicity.