PT  - JOURNAL ARTICLE
AU  - Simpson, David M.
TI  - HIV-associated PML: Changing epidemiology and clinical approach
AID  - 10.3949/ccjm.78.s2.06
DP  - 2011 Nov 01
TA  - Cleveland Clinic Journal of Medicine
PG  - S24--S27
VI  - 78
IP  - 11 suppl 2
4099  - http://www.ccjm.org/content/78/11_suppl_2/S24.short
4100  - http://www.ccjm.org/content/78/11_suppl_2/S24.full
SO  - Cleve Clin J Med2011 Nov 01; 78
AB  - Despite the availability of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) infection, there has not been a dramatic decrease in the frequency of progressive multifocal leukoencephalopathy (PML) in the HIV-infected population. Usually a multifocal progressive disease of nonenhancing lesions in white matter, PML can have distinct characteristics in HIV-infected patients, including unifocal static lesions of faint contrast enhancement on imaging and involvement of gray matter. A syndrome of cerebellar degeneration has been described in association with HIV infection in patients positive for JC virus, the papovavirus responsible for PML. The standard of care for HIV-associated PML is HAART to achieve immunologic recovery and optimal HIV virologic control. The prognosis of PML has improved greatly since the advent of HAART