RT Journal Article
SR Electronic
T1 Omeprazole and clopidogrel: Should clinicians be worried?
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 113
OP 116
DO 10.3949/ccjm.77a.09173
VO 77
IS 2
A1 Jeremiah P. Depta
A1 Deepak L. Bhatt
YR 2010
UL http://www.ccjm.org/content/77/2/113.abstract
AB The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascular outcomes when omeprazole was given with clopidogrel. We recommend that physicians continue to prescribe a proton pump inhibitor for patients receiving dual antiplatelet therapy who are at risk of gastrointestinal bleeding or have an indication for use of a proton pump inhibitor.