TY - JOUR T1 - Omeprazole and clopidogrel: Should clinicians be worried? JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 113 LP - 116 DO - 10.3949/ccjm.77a.09173 VL - 77 IS - 2 AU - Jeremiah P. Depta AU - Deepak L. Bhatt Y1 - 2010/02/01 UR - http://www.ccjm.org/content/77/2/113.abstract N2 - The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascular outcomes when omeprazole was given with clopidogrel. We recommend that physicians continue to prescribe a proton pump inhibitor for patients receiving dual antiplatelet therapy who are at risk of gastrointestinal bleeding or have an indication for use of a proton pump inhibitor. ER -