%0 Journal Article %A Steven A. Lietman %T Soft-tissue sarcomas: Overview of management, with a focus on surgical treatment considerations %D 2010 %R 10.3949/ccjm.77.s1.03 %J Cleveland Clinic Journal of Medicine %P S13-S17 %V 77 %N 3 suppl 1 %X Patients with soft-tissue sarcomas generally present with a mass that is increasing in size; the presence or absence of pain is not typically predictive of malignancy. While magnetic resonance imaging (MRI) can identify a few soft-tissue lesion types as benign, diagnosis of most lesions requires a careful biopsy, preferably performed by or in consultation with the surgeon who would do an eventual resection. If biopsy confirms a diagnosis of sarcoma, MRI-guided surgical resection with a wide margin is the mainstay of treatment. Neoadjuvant radiation therapy and chemotherapy have not been of proven benefit in well-controlled studies but are frequently used as adjuncts. Resections with wide margins are generally associated with a low (< 10%) risk of recurrence. %U https://www.ccjm.org/content/ccjom/77/3_suppl_1/S13.full.pdf