RT Journal Article SR Electronic T1 Breaking the cycle of medication overuse headache JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 236 OP 242 DO 10.3949/ccjm.77a.09147 VO 77 IS 4 A1 Stewart J. Tepper A1 Deborah E. Tepper YR 2010 UL http://www.ccjm.org/content/77/4/236.abstract AB When patients who have frequent, disabling migraines take medications to relieve their symptoms, they run the risk that the attacks will increase in frequency to daily or near-daily as a rebound effect comes into play. This pattern, called medication overuse headache, is more likely to happen with butalbital and opioids than with migraine-specific drugs, as partial responses lead to recurrence, repeat dosing, and, eventually, overuse. Breaking the cycle involves weaning the patient from the overused medications, setting up a preventive regimen, and setting strict limits on the use of medications to relieve acute symptoms.