PT - JOURNAL ARTICLE AU - Faiman, Beth AU - Licata, Angelo A. TI - New tools for detecting occult monoclonal gammopathy, a cause of secondary osteoporosis AID - 10.3949/ccjm.77a.09091 DP - 2010 Apr 01 TA - Cleveland Clinic Journal of Medicine PG - 273--278 VI - 77 IP - 4 4099 - http://www.ccjm.org/content/77/4/273.short 4100 - http://www.ccjm.org/content/77/4/273.full SO - Cleve Clin J Med2010 Apr 01; 77 AB - Most patients with multiple myeloma or other monoclonal gammopathies present with anemia, hypercalcemia, or renal insufficiency. However, osteoporosis may be the first sign. Measuring the concentration and ratio of free light chains in the serum can help detect monoclonal gammopathy and help to differentiate myeloma-related bone loss from other secondary forms of osteoporosis.