PT  - JOURNAL ARTICLE
AU  - David W. Barry
AU  - Michael F. Vaezi
TI  - Laryngopharyngeal reflux: More questions than answers
AID  - 10.3949/ccjm.77a.09121
DP  - 2010 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 327--334
VI  - 77
IP  - 5
4099  - http://www.ccjm.org/content/77/5/327.short
4100  - http://www.ccjm.org/content/77/5/327.full
SO  - Cleve Clin J Med2010 May 01; 77
AB  - Laryngopharyngeal reflux (LPR), an extraesophageal variant of gastroesophageal reflux disease, is associated with hoarseness, chronic cough, throat-clearing, sore throat, and dysphagia. But because these symptoms are nonspecific, laryngoscopy is often done and the diagnosis of LPR is considered if edema, erythema, ventricular obliteration, pseudosulcus, or postcricoid hyperplasia is noted. Most patients with suspected LPR are given a 2-month trial of a proton pump inhibitor. Yet there is still little or no solid evidence on which to base the diagnosis or the treatment of LPR. We review the current understanding of the pathophysiology and discuss current diagnostic tests and treatment regimens in patients with suspected LPR.