%0 Journal Article %A Sandipan Pati %A Andreas v. Alexopoulos %T Pharmacoresistant epilepsy: From pathogenesis to current and emerging therapies %D 2010 %R 10.3949/ccjm.77a.09061 %J Cleveland Clinic Journal of Medicine %P 457-467 %V 77 %N 7 %X Almost one-third of people with epilepsy continue to have seizures despite appropriate antiepileptic drug treatment, placing them at considerable risk of cognitive and psychosocial dysfunction and death. We recommend early referral to an epilepsy center when seizures are difficult to control. %U https://www.ccjm.org/content/ccjom/77/7/457.full.pdf