PT - JOURNAL ARTICLE AU - Sandipan Pati AU - Andreas v. Alexopoulos TI - Pharmacoresistant epilepsy: From pathogenesis to current and emerging therapies AID - 10.3949/ccjm.77a.09061 DP - 2010 Jul 01 TA - Cleveland Clinic Journal of Medicine PG - 457--467 VI - 77 IP - 7 4099 - http://www.ccjm.org/content/77/7/457.short 4100 - http://www.ccjm.org/content/77/7/457.full SO - Cleve Clin J Med2010 Jul 01; 77 AB - Almost one-third of people with epilepsy continue to have seizures despite appropriate antiepileptic drug treatment, placing them at considerable risk of cognitive and psychosocial dysfunction and death. We recommend early referral to an epilepsy center when seizures are difficult to control.