TY - JOUR T1 - Pharmacoresistant epilepsy: From pathogenesis to current and emerging therapies JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 457 LP - 467 DO - 10.3949/ccjm.77a.09061 VL - 77 IS - 7 AU - Sandipan Pati AU - Andreas v. Alexopoulos Y1 - 2010/07/01 UR - http://www.ccjm.org/content/77/7/457.abstract N2 - Almost one-third of people with epilepsy continue to have seizures despite appropriate antiepileptic drug treatment, placing them at considerable risk of cognitive and psychosocial dysfunction and death. We recommend early referral to an epilepsy center when seizures are difficult to control. ER -