RT Journal Article SR Electronic T1 Pharmacoresistant epilepsy: From pathogenesis to current and emerging therapies JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 457 OP 467 DO 10.3949/ccjm.77a.09061 VO 77 IS 7 A1 Sandipan Pati A1 Andreas v. Alexopoulos YR 2010 UL http://www.ccjm.org/content/77/7/457.abstract AB Almost one-third of people with epilepsy continue to have seizures despite appropriate antiepileptic drug treatment, placing them at considerable risk of cognitive and psychosocial dysfunction and death. We recommend early referral to an epilepsy center when seizures are difficult to control.