PT  - JOURNAL ARTICLE
AU  - Chirag Vaidya
AU  - Warren Ho
AU  - Benjamin J. Freda
TI  - Management of hyponatremia: Providing treatment and avoiding harm
AID  - 10.3949/ccjm.77a.08051
DP  - 2010 Oct 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 715--726
VI  - 77
IP  - 10
4099  - http://www.ccjm.org/content/77/10/715.short
4100  - http://www.ccjm.org/content/77/10/715.full
SO  - Cleve Clin J Med2010 Oct 01; 77
AB  - Hyponatremia, in its most severe form, requires urgent infusion of hypertonic saline to correct cerebral edema. However, overly rapid correction of chronic hyponatremia can cause osmotic demyelination syndrome. The authors review the treatment of hyponatremia in order to provide clinicians with a sound approach in a variety of settings in which severity, symptoms, and underlying disease states influence therapy. Also discussed is the current role of vasopressin antagonists in treatment.