PT  - JOURNAL ARTICLE
AU  - Geldmacher, David S.
TI  - Alzheimer disease prevention: Focus on cardiovascular risk, not amyloid?
AID  - 10.3949/ccjm.77gr.2010
DP  - 2010 Oct 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 689--704
VI  - 77
IP  - 10
4099  - http://www.ccjm.org/content/77/10/689.short
4100  - http://www.ccjm.org/content/77/10/689.full
SO  - Cleve Clin J Med2010 Oct 01; 77
AB  - Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.