RT Journal Article
SR Electronic
T1 Alzheimer disease prevention: Focus on cardiovascular risk, not amyloid?
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 689
OP 704
DO 10.3949/ccjm.77gr.2010
VO 77
IS 10
A1 Geldmacher, David S.
YR 2010
UL http://www.ccjm.org/content/77/10/689.abstract
AB Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.