PT - JOURNAL ARTICLE AU - Abraham, Joellyn M. AU - Cho, Leslie TI - The homocysteine hypothesis: Still relevant to the prevention and treatment of cardiovascular disease? AID - 10.3949/ccjm.77a.10036 DP - 2010 Dec 01 TA - Cleveland Clinic Journal of Medicine PG - 911--918 VI - 77 IP - 12 4099 - http://www.ccjm.org/content/77/12/911.short 4100 - http://www.ccjm.org/content/77/12/911.full SO - Cleve Clin J Med2010 Dec 01; 77 AB - Although evidence suggests that the homocysteine hypothesis is still relevant as a predictor of cardiovascular risk, we cannot conclude that measuring the homocysteine level is useful in guiding treatment. Furthermore, studies of primary and secondary prevention show no evidence that taking folic acid or other B vitamins lowers the risk of cardiovascular events.