RT Journal Article SR Electronic T1 Vitamin D and the heart: Why we need large-scale clinical trials JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 903 OP 910 DO 10.3949/ccjm.77gr.10004 VO 77 IS 12 A1 Manson, Joann E. YR 2010 UL http://www.ccjm.org/content/77/12/903.abstract AB Although vitamin D supplementation appears to be a promising intervention for reducing risks of cancer, cardiovascular disease, and other chronic diseases, existing evidence on its benefits and risks is limited and inconclusive. Recruitment is now under way for the Vitamin D and Omega-3 Trial (VITAL), the first large-scale randomized clinical trial of these nutritional agents for the primary prevention of cancer and cardiovascular disease.