PT - JOURNAL ARTICLE AU - Manzi, Susan TI - Lupus update: Perspective and clinical pearls AID - 10.3949/ccjm.76a.gr005 DP - 2009 Feb 01 TA - Cleveland Clinic Journal of Medicine PG - 137--142 VI - 76 IP - 2 4099 - http://www.ccjm.org/content/76/2/137.short 4100 - http://www.ccjm.org/content/76/2/137.full SO - Cleve Clin J Med2009 Feb 01; 76 AB - Patients with systemic lupus erythematosus (SLE, lupus) have a markedly better survival rate today than they did 50 years ago, but they face a greater risk of cancer, cardiovascular disease, and osteoporosis at early ages. With better understanding of the immunological mechanisms of the disease, new avenues of therapy are emerging.