RT Journal Article SR Electronic T1 Lupus update: Perspective and clinical pearls JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 137 OP 142 DO 10.3949/ccjm.76a.gr005 VO 76 IS 2 A1 Manzi, Susan YR 2009 UL http://www.ccjm.org/content/76/2/137.abstract AB Patients with systemic lupus erythematosus (SLE, lupus) have a markedly better survival rate today than they did 50 years ago, but they face a greater risk of cancer, cardiovascular disease, and osteoporosis at early ages. With better understanding of the immunological mechanisms of the disease, new avenues of therapy are emerging.