RT Journal Article
SR Electronic
T1 The current state of antiplatelet therapy in acute coronary syndromes: The data and the real world
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S16
OP S23
DO 10.3949/ccjm.76.s1.03
VO 76
IS 4 suppl 1
A1 Bhatt, Deepak L.
A1 Peacock, W. Frank
A1 Alexander, John H.
YR 2009
UL http://www.ccjm.org/content/76/4_suppl_1/S16.abstract
AB Managing antiplatelet therapy for patients with acute coronary syndromes (ACS) is complex, and current therapy options and approaches for these patients are suboptimal. Despite the use of available antiplatelet therapies—aspirin, clopidogrel, and the parenteral glycoprotein IIb/IIIa inhibitors—recurrence of ischemic events in patients with ACS continues to rise over time. Moreover, bleeding remains an important—and often underappreciated—risk with these therapies, and national registries demonstrate that dosing of antiplatelet therapies frequently strays from evidence-based guidelines. Recent quality-improvement initiatives developed in conjunction with national registries of patients with ACS promise to improve adherence to guidelines through hospital-specific performance reports. More evidence-based use of existing and emerging anti-platelet agents has the potential to improve both ischemic and bleeding outcomes in patients with ACS.