%0 Journal Article %A Mike J.L. Dejongste %A Gert J. Terhorst %A Robert D. Foreman %T Basic research models for the study of underlying mechanisms of electrical neuromodulation and ischemic heart-brain interactions %D 2009 %R 10.3949/ccjm.76.s2.09 %J Cleveland Clinic Journal of Medicine %P S41-S46 %V 76 %N 4 suppl 2 %X The study of mechanisms of action underlying the use of electrical neuromodulation for angina and myocardial ischemia may illuminate heart-brain interactions that influence these conditions. To investigate these mechanisms of action, we initiated a neurocardiology program in the 1990s. This review discusses the experimental models we have studied to unravel the heart-brain interactions involved in the use of electrical neuromodulation for ischemic disease. %U https://www.ccjm.org/content/ccjom/76/4_suppl_2/S41.full.pdf