TY - JOUR T1 - Cardiac sympathetic denervation preceding motor signs in Parkinson disease JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - S47 LP - S50 DO - 10.3949/ccjm.76.s2.10 VL - 76 IS - 4 suppl 2 AU - David S. Goldstein AU - Yehonatan Sharabi AU - Barbara I. Karp AU - Oladi Bentho AU - Ahmed Saleem AU - Karel Pacak AU - Graeme Eisenhofer Y1 - 2009/02/01 UR - http://www.ccjm.org/content/76/4_suppl_2/S47.abstract N2 - There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD. ER -