RT Journal Article
SR Electronic
T1 Cardiac sympathetic denervation preceding motor signs in Parkinson disease
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S47
OP S50
DO 10.3949/ccjm.76.s2.10
VO 76
IS 4 suppl 2
A1 Goldstein, David S.
A1 Sharabi, Yehonatan
A1 Karp, Barbara I.
A1 Bentho, Oladi
A1 Saleem, Ahmed
A1 Pacak, Karel
A1 Eisenhofer, Graeme
YR 2009
UL http://www.ccjm.org/content/76/4_suppl_2/S47.abstract
AB There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.