PT  - JOURNAL ARTICLE
AU  - Roy L. Silverstein
TI  - Inflammation, atherosclerosis, and arterial thrombosis: Role of the scavenger receptor CD36
AID  - 10.3949/ccjm.76.s2.06
DP  - 2009 Feb 01
TA  - Cleveland Clinic Journal of Medicine
PG  - S27--S30
VI  - 76
IP  - 4 suppl 2
4099  - http://www.ccjm.org/content/76/4_suppl_2/S27.short
4100  - http://www.ccjm.org/content/76/4_suppl_2/S27.full
SO  - Cleve Clin J Med2009 Feb 01; 76
AB  - The CD36 scavenger receptor recognizes oxidized low-density lipoprotein (LDL) and cell-derived microparticles. It is expressed on macrophages and platelets and is a mediator of both atherogenesis and thrombosis. Macrophages from CD36-null mice have a defect in foam cell formation in response to exposure to oxidized LDL, and CD36-null mice fed an atherogenic Western diet have significantly less atherosclerosis than their wild-type counterparts. On platelets, CD36 recognition of oxidized LDL contributes to their activation and provides a mechanistic link between hyperlipidemia, oxidant stress, and the prothrombotic state. Cell-derived microparticles are also major ligands for CD36 and contribute to thrombus formation in a CD36-dependent manner even in the absence of hyperlipidemia. CD36 deficiency in mice is associated with inhibition of thrombus formation and with a reduction in microparticle accumulation in thrombi. Targeting CD36 is a promising avenue for the treatment of atheroinflammatory disorders.