PT - JOURNAL ARTICLE AU - Olusegun Osinbowale AU - Monzr Al Malki AU - Andrew Schade AU - John R. Bartholomew TI - An algorithm for managing warfarin resistance AID - 10.3949/ccjm.76a.09062 DP - 2009 Dec 01 TA - Cleveland Clinic Journal of Medicine PG - 724--730 VI - 76 IP - 12 4099 - http://www.ccjm.org/content/76/12/724.short 4100 - http://www.ccjm.org/content/76/12/724.full SO - Cleve Clin J Med2009 Dec 01; 76 AB - Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.