RT Journal Article SR Electronic T1 An algorithm for managing warfarin resistance JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 724 OP 730 DO 10.3949/ccjm.76a.09062 VO 76 IS 12 A1 Olusegun Osinbowale A1 Monzr Al Malki A1 Andrew Schade A1 John R. Bartholomew YR 2009 UL http://www.ccjm.org/content/76/12/724.abstract AB Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.