RT Journal Article
SR Electronic
T1 An algorithm for managing warfarin resistance
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 724
OP 730
DO 10.3949/ccjm.76a.09062
VO 76
IS 12
A1 Osinbowale, Olusegun
A1 Malki, Monzr Al
A1 Schade, Andrew
A1 Bartholomew, John R.
YR 2009
UL http://www.ccjm.org/content/76/12/724.abstract
AB Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.