TY - JOUR T1 - An algorithm for managing warfarin resistance JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 724 LP - 730 DO - 10.3949/ccjm.76a.09062 VL - 76 IS - 12 AU - Olusegun Osinbowale AU - Monzr Al Malki AU - Andrew Schade AU - John R. Bartholomew Y1 - 2009/12/01 UR - http://www.ccjm.org/content/76/12/724.abstract N2 - Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance. ER -