RT Journal Article
SR Electronic
T1 Redefining treatment success in type 2 diabetes mellitus: Comprehensive targeting of core defects
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S39
OP S47
DO 10.3949/ccjm.76.s5.06
VO 76
IS 12 suppl 5
A1 Laurence Kennedy
A1 William T. Cefalu
A1 Robert J. Richards
A1 Lydia Y. Melendez-Ramirez
YR 2009
UL http://www.ccjm.org/content/76/12_suppl_5/S39.abstract
AB Despite advances in diagnosis and treatment, type 2 diabetes mellitus (T2DM), overweight/obesity, cardiovascular disease, and their sequelae are major public health burdens worldwide. The understanding of the pathophysiology of T2DM has traditionally emphasized decreased insulin secretion and increased insulin resistance, but evolving concepts now include the role of incretin hormones in disease progression. A comprehensive approach to managing patients with T2DM requires targeting both the fundamental defects of the disease and its comorbidities, including the sequelae of nonoptimal control of blood glucose, blood pressure, body weight, and lipids. Newer antidiabetes agents, such as the glucagon-like peptide–1 (GLP-1) receptor agonists and the dipeptidyl peptidase–4 (DPP-4) inhibitors, address fundamental defects related to glycemic control in T2DM and may have potential effects on other markers of cardiovascular risk. A redefinition of treatment success may be warranted as more data become available.