RT Journal Article SR Electronic T1 The STAR*D study: Treating depression in the real world JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 57 OP 66 VO 75 IS 1 A1 Bradley N. Gaynes A1 A. John Rush A1 Madhukar H. Trivedi A1 Stephen R. Wisniewski A1 Donald Spencer A1 Maurizio Fava YR 2008 UL http://www.ccjm.org/content/75/1/57.abstract AB The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut “winner,” it does provide guidance on how to start therapy and how to proceed if initial treatment fails.