RT Journal Article
SR Electronic
T1 Heart-brain interactions in cardiac arrhythmias: Role of the autonomic nervous system
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S94
OP S96
VO 75
IS 3 suppl 2
A1 Zipes, Douglas P.
YR 2008
UL http://www.ccjm.org/content/75/3_suppl_2/S94.abstract
AB The autonomic nervous system plays an important role in the genesis of ventricular arrhythmias and sudden cardiac death. Evidence is substantial for a neural component in sudden cardiac death. Sympathetic nerve sprouting and regional myocardial hyperinnervation following myocardial injury promote cardiac arrhythmia and sudden cardiac death through several potential mechanisms. Modulating autonomic tone is a potential method to reduce the risk of ventricular arrhythmias. Thoracic spinal cord stimulation is showing promise as a treatment for refractory angina. In addition, spinal cord stimulation has protected against ventricular tachycardia/ventricular fibrillation in animal models of postinfarction heart failure.