RT Journal Article
SR Electronic
T1 Inflammation as a link between brain injury and heart damage: The model of subarachnoid hemorrhage
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S26
OP S30
VO 75
IS 3 suppl 2
A1 Mashaly, Hazem Antar
A1 Provencio, J. Javier
YR 2008
UL http://www.ccjm.org/content/75/3_suppl_2/S26.abstract
AB Subarachnoid hemorrhage (SAH) serves as a good model for the study of heart-brain interactions because it is associated with both a high incidence of arrhythmia and a low prevalence of coronary heart disease. The pathophysiology of cardiac abnormalities in SAH is unsettled. Initial theories focused on sustained stimulation of cardiomyocytes at sympathetic nerve endings, but recent data suggest that dysfunction of the parasympathetic nervous system may contribute as well. We believe that the coupling of cate-cholamine release with parasympathetic dysfunction may allow unchecked inflammation that leads to myocardial dysfunction and cell death. We have developed a novel murine model of SAH to explore these potential inflammatory underpinnings of cardiac damage in SAH.