PT  - JOURNAL ARTICLE
AU  - Walter, Benjamin L.
TI  - Cardiovascular autonomic dysfunction in patients with movement disorders
DP  - 2008 Mar 01
TA  - Cleveland Clinic Journal of Medicine
PG  - S54--S58
VI  - 75
IP  - 3 suppl 2
4099  - http://www.ccjm.org/content/75/3_suppl_2/S54.short
4100  - http://www.ccjm.org/content/75/3_suppl_2/S54.full
SO  - Cleve Clin J Med2008 Mar 01; 75
AB  - Autonomic dysfunction is common in parkinsonian syndromes, particularly those involving dysregulation of alpha-synuclein, and may result from neurodegeneration in autonomic regulatory regions of the brain or peripherial autonomic ganglia. The most limiting cardiovascular autonomic dysfunction in these diseases is orthostatic hypotension, which is particularly prominent in multiple system atrophy. Postprandial hypotension and supine hypertension, as well as dopaminergic therapy, often complicate the management of orthostatic hypotension in patients with parkinsonian syndromes.