RT Journal Article
SR Electronic
T1 Insular Alzheimer disease pathology and the psychometric correlates of mortality
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP S97
OP S99
VO 75
IS 3 suppl 2
A1 Royall, Donald R.
YR 2008
UL http://www.ccjm.org/content/75/3_suppl_2/S97.abstract
AB Right hemisphere dysfunction is associated with mortality in Alzheimer’s disease (AD) and other neurologic conditions. These associations may be mediated by insular pathology, as insular lesions result in demonstrable changes in cardiovascular and autonomic control. AD affects the insulae at a preclinical stage, and insular AD pathology may be present in up to 40% of nondemented septuagenarians and octogenarians. This pathology can affect in vivo cardiac conduction and thereby dispose to cardiac arrhythmias and sudden death. Thus, AD pathology should be considered as a possible explanation for autonomic morbidity and mortality in nondemented elderly persons.