PT  - JOURNAL ARTICLE
AU  - Demirjian, Sevag G.
AU  - Nurko, Saul
TI  - Anemia of chronic kidney disease: When normalcy becomes undesirable
DP  - 2008 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 353--356
VI  - 75
IP  - 5
4099  - http://www.ccjm.org/content/75/5/353.short
4100  - http://www.ccjm.org/content/75/5/353.full
SO  - Cleve Clin J Med2008 May 01; 75
AB  - In patients with chronic kidney disease and renal failure, hemoglobin levels have been rising in parallel with more intensive use of erythropoiesis-stimulating agents (ESAs). However, several recent studies indicate that raising hemoglobin to normal levels with ESAs can be too much of a good thing. Compared with partial correction, normalization of hemoglobin did not improve outcome, and it may have led to more frequent adverse events. The US Food and Drug Administration (FDA) now recommends a hemoglobin goal in the range of 10 to 12 g/dL.