RT Journal Article SR Electronic T1 The gout diagnosis JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP S17 OP S21 VO 75 IS 7 suppl 5 A1 Mandell, Brian F. A1 Dore, Robin K. YR 2008 UL http://www.ccjm.org/content/75/7_suppl_5/S17.abstract AB Synovial fluid aspiration and analysis is the gold standard for making the diagnosis of gout but is not always performed when indicated in clinical practice. In clinical situations when joint aspiration simply cannot be performed, a presumptive (or clinical) diagnosis of gout may be made in consultation with published recommendations and criteria from expert societies. A thorough patient history and physical examination are critical to a presumptive diagnosis of gout, as is serum urate measurement at the time of an acute attack and at follow-up 2 weeks later.