PT  - JOURNAL ARTICLE
AU  - Mandell, Brian F.
AU  - Edwards, N. Lawrence
TI  - The role of hyperuricemia and gout in kidney and cardiovascular disease
DP  - 2008 Jul 01
TA  - Cleveland Clinic Journal of Medicine
PG  - S13--S16
VI  - 75
IP  - 7 suppl 5
4099  - http://www.ccjm.org/content/75/7_suppl_5/S13.short
4100  - http://www.ccjm.org/content/75/7_suppl_5/S13.full
SO  - Cleve Clin J Med2008 Jul 01; 75
AB  - Elevated serum urate levels are recognized as leading to gouty arthritis, tophi formation, and uric acid kidney stones. While serum urate elevations have long been associated with renal disease, they are not usually considered to have a causal role in kidney dysfunction. However, recent epidemiologic studies have identified serum urate elevations as an independent risk factor for chronic kidney disease. Hyperuricemia has also been found to be an independent risk factor for cardiovascular disease and hypertension. An animal model of mild hyperuricemia has shed new light on a potential mechanism of microvascular changes leading to endothelial dysfunction, a precursor to both coronary artery disease and hypertension. Additional animal studies and recent epidemiologic findings have provided further evidence that soluble urate is a risk factor for nonarticular disease.