RT Journal Article SR Electronic T1 When and how to fix a ‘hole in the heart’: Approach to ASD and PFO JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 137 OP 147 VO 74 IS 2 A1 Krasuski, Richard A. YR 2007 UL http://www.ccjm.org/content/74/2/137.abstract AB Abnormalities in the atrial septum range in severity from patent foramen ovale (PFO), a residual cardiac structure found in approximately 25% of the general population, to uncommon, complex lesions associated with significant shunt flow and heart enlargement. While correcting some of these abnormalities is beneficial, most other defects warrant correction only under very specific circumstances.