PT  - JOURNAL ARTICLE
AU  - Chisolm, Guy M.
AU  - Sheehan, James G.
TI  - Fraud, conflict of interest, and other enforcement issues in clinical research
DP  - 2007 Mar 01
TA  - Cleveland Clinic Journal of Medicine
PG  - S63--S67
VI  - 74
IP  - 3 suppl 2
4099  - http://www.ccjm.org/content/74/3_suppl_2/S63.short
4100  - http://www.ccjm.org/content/74/3_suppl_2/S63.full
SO  - Cleve Clin J Med2007 Mar 01; 74
AB  - Fraud in scientific research is a widespread problem. It can involve falsifying data or documents, or knowingly failing to comply with regulations protecting research participants. Fraud can be committed by individuals, institutions, or corporations; in the context of research, fraud often is motivated by considerations beyond financial gain. Institutional review boards (IRBs) are designed to ensure that researchers comply with human research subject protections, including conflict-of-interest controls, but IRBs may fail to do so if investigators avoid existing IRB processes or if IRB members do not take responsibility for addressing actual or potential conflicts of interest.