RT Journal Article SR Electronic T1 Benign prostatic hyperplasia: When to ‘watch and wait,’ when and how to treat JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP S15 OP S20 VO 74 IS 5 suppl 3 A1 Rosenberg, Matt T. A1 Lakin, Milton M. A1 Staskin, David R. A1 Levy, Albert A1 Samraj, George P. YR 2007 UL http://www.ccjm.org/content/74/5_suppl_3/S15.abstract AB Benign prostatic hyperplasia (BPH) is a clinical diagnosis. While BPH is a common cause of lower urinary tract symptoms (LUTS) in men, LUTS can signify a number of other disease states. For this reason, the patient evaluation, which includes a digital rectal examination, and careful differential diagnosis are crucial in men with LUTS. Many men with BPH are asymptomatic, and many others are not bothered by their symptoms; watchful waiting is appropriate management for these patients. When symptoms affect quality of life, pharmacologic therapy should be an option; choices include an alpha-blocker, a 5 alpha-reductase inhibitor, or, for men with larger prostates, a combination of the two. Surgical intervention is indicated when BPH leads to other medical complications, including urinary retention and renal insufficiency.