PT - JOURNAL ARTICLE AU - Mathews, Manu AU - Muzina, David J. TI - Atypical antipsychotics: New drugs, new challenges DP - 2007 Aug 01 TA - Cleveland Clinic Journal of Medicine PG - 597--606 VI - 74 IP - 8 4099 - http://www.ccjm.org/content/74/8/597.short 4100 - http://www.ccjm.org/content/74/8/597.full SO - Cleve Clin J Med2007 Aug 01; 74 AB - Compared with the first-generation, or “typical” antipsychotic drugs, second-generation or atypical antipsychotics cause fewer extrapyramidal (motor) problems, but they pose new challenges, as they often contribute to metabolic disturbances such as weight gain, hyperlipidemia, insulin resistance, and type 2 diabetes mellitus. Patients taking atypical antipsychotics should be monitored for glycemic and cardiovascular risk factors and should receive treatment for such problems as they arise.