RT Journal Article SR Electronic T1 Atypical antipsychotics: New drugs, new challenges JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 597 OP 606 VO 74 IS 8 A1 Mathews, Manu A1 Muzina, David J. YR 2007 UL http://www.ccjm.org/content/74/8/597.abstract AB Compared with the first-generation, or “typical” antipsychotic drugs, second-generation or atypical antipsychotics cause fewer extrapyramidal (motor) problems, but they pose new challenges, as they often contribute to metabolic disturbances such as weight gain, hyperlipidemia, insulin resistance, and type 2 diabetes mellitus. Patients taking atypical antipsychotics should be monitored for glycemic and cardiovascular risk factors and should receive treatment for such problems as they arise.