PT - JOURNAL ARTICLE AU - Susan J. Rehm AU - Alpesh N. Amin AU - James I. Merlino AU - Mark A. Malangoni TI - Complicated skin and soft-tissue infections: Diagnostic approach and empiric treatment options DP - 2007 Aug 01 TA - Cleveland Clinic Journal of Medicine PG - S21--S28 VI - 74 IP - 8 suppl 4 4099 - http://www.ccjm.org/content/74/8_suppl_4/S21.short 4100 - http://www.ccjm.org/content/74/8_suppl_4/S21.full SO - Cleve Clin J Med2007 Aug 01; 74 AB - Skin and soft-tissue infections are common and generally are uncomplicated at the time of initial presentation. However, these infections can worsen quickly when there are delays in presentation and treatment. Upon encountering these infections, physicians must respond quickly with an appropriate therapeutic plan and be aware of trends in microbial resistance in order to optimize patient care.