RT Journal Article SR Electronic T1 Complicated skin and soft-tissue infections: Diagnostic approach and empiric treatment options JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP S21 OP S28 VO 74 IS 8 suppl 4 A1 Susan J. Rehm A1 Alpesh N. Amin A1 James I. Merlino A1 Mark A. Malangoni YR 2007 UL http://www.ccjm.org/content/74/8_suppl_4/S21.abstract AB Skin and soft-tissue infections are common and generally are uncomplicated at the time of initial presentation. However, these infections can worsen quickly when there are delays in presentation and treatment. Upon encountering these infections, physicians must respond quickly with an appropriate therapeutic plan and be aware of trends in microbial resistance in order to optimize patient care.