RT Journal Article
SR Electronic
T1 The two faces of the ‘good’ cholesterol
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 697
OP 705
VO 74
IS 10
A1 Ansell, Benjamin J.
YR 2007
UL http://www.ccjm.org/content/74/10/697.abstract
AB Although a low level of high-density lipoprotein (HDL) cholesterol is a useful clinical predictor of coronary heart disease, raising the HDL cholesterol level does not necessarily lower this risk. Part of the explanation for this paradox may be that, under certain conditions, HDL either can be less functional as an antioxidant or can even enhance the oxidation and inflammation associated with atherosclerotic plaque. Thus, the functional properties of HDL—not simply the level—may need to be considered and optimized.