PT  - JOURNAL ARTICLE
AU  - Jabbar, Danish A.
AU  - Davison, Glenn
AU  - Muslin, Anthony J.
TI  - Getting the iron out: Preventing and treating heart failure in transfusion-dependent thalassemia
DP  - 2007 Nov 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 807--816
VI  - 74
IP  - 11
4099  - http://www.ccjm.org/content/74/11/807.short
4100  - http://www.ccjm.org/content/74/11/807.full
SO  - Cleve Clin J Med2007 Nov 01; 74
AB  - Congestive heart failure is the most common cause of death in patients with thalassemia, as chronic accumulation of iron due to regular blood transfusions leads to biventricular systolic dysfunction and death at a very young age. The quantity of iron deposited in the heart is a key determinant of outcome. Early diagnosis and intensive chelation of the cardiac iron can avert heart failure and its fatal outcome.