RT Journal Article
SR Electronic
T1 Getting the iron out: Preventing and treating heart failure in transfusion-dependent thalassemia
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 807
OP 816
VO 74
IS 11
A1 Jabbar, Danish A.
A1 Davison, Glenn
A1 Muslin, Anthony J.
YR 2007
UL http://www.ccjm.org/content/74/11/807.abstract
AB Congestive heart failure is the most common cause of death in patients with thalassemia, as chronic accumulation of iron due to regular blood transfusions leads to biventricular systolic dysfunction and death at a very young age. The quantity of iron deposited in the heart is a key determinant of outcome. Early diagnosis and intensive chelation of the cardiac iron can avert heart failure and its fatal outcome.