TY - JOUR T1 - Immunological reversal of digitalis toxicity by Fab fragments of digoxin-specific antibodies JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 43 LP - 48 VL - 54 IS - 1 AU - Daniel M. Cooper AU - James D. Maloney AU - Lisa A. Cooper AU - James R. Hodgman AU - Lon W. Castle Y1 - 1987/01/01 UR - http://www.ccjm.org/content/54/1/43.abstract N2 - Severe digitalis toxicity is associated with a high mortality. We present a case of advanced digoxin toxicity successfully treated with digoxin-specific antibody Fab fragments, and discuss its mechanism of action. A review of the pharmacokinetics of digitalis as well as the mechanisms of cardiotoxicity and its conventional treatment is presented. ER -