RT Journal Article
SR Electronic
T1 Immunological reversal of digitalis toxicity by Fab fragments of digoxin-specific antibodies
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 43
OP 48
VO 54
IS 1
A1 Cooper, Daniel M.
A1 Maloney, James D.
A1 Cooper, Lisa A.
A1 Hodgman, James R.
A1 Castle, Lon W.
YR 1987
UL http://www.ccjm.org/content/54/1/43.abstract
AB Severe digitalis toxicity is associated with a high mortality. We present a case of advanced digoxin toxicity successfully treated with digoxin-specific antibody Fab fragments, and discuss its mechanism of action. A review of the pharmacokinetics of digitalis as well as the mechanisms of cardiotoxicity and its conventional treatment is presented.