PT  - JOURNAL ARTICLE
AU  - Foutch, P. Gregory
AU  - Ferguson, D. Roy
AU  - Tuthill, Ralph J.
TI  - Enflurane-induced hepatitis with prominent cholestasis
DP  - 1987 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 210--213
VI  - 54
IP  - 3
4099  - http://www.ccjm.org/content/54/3/210.short
4100  - http://www.ccjm.org/content/54/3/210.full
SO  - Cleve Clin J Med1987 May 01; 54
AB  - Previously reported cases of enflurane-induced hepatitis share similar clinical, biochemical, and histological features. Systemic symptoms follow a brief latent period after exposure to the anesthetic. Aminotransferase abnormalities predominate and coincide with the histological finding of centrilobular necrosis. The authors describe a case of enflurane-induced hepatitis with typical clinical manifestations associated with mixed hepatocellular and cholestatic liver-function-test abnormalities. Biochemical cholestasis eventually predominated and spuriously simulated an extrahepatic bile duct obstruction. Results of a percutaneous liver biopsy showed a mixed hepatocanalicular drug reaction.