RT Journal Article
SR Electronic
T1 Enflurane-induced hepatitis with prominent cholestasis
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 210
OP 213
VO 54
IS 3
A1 Foutch, P. Gregory
A1 Ferguson, D. Roy
A1 Tuthill, Ralph J.
YR 1987
UL http://www.ccjm.org/content/54/3/210.abstract
AB Previously reported cases of enflurane-induced hepatitis share similar clinical, biochemical, and histological features. Systemic symptoms follow a brief latent period after exposure to the anesthetic. Aminotransferase abnormalities predominate and coincide with the histological finding of centrilobular necrosis. The authors describe a case of enflurane-induced hepatitis with typical clinical manifestations associated with mixed hepatocellular and cholestatic liver-function-test abnormalities. Biochemical cholestasis eventually predominated and spuriously simulated an extrahepatic bile duct obstruction. Results of a percutaneous liver biopsy showed a mixed hepatocanalicular drug reaction.